Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease?
نویسندگان
چکیده
منابع مشابه
Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease?
In Parkinson's disease (PD) depletion of dopamine in the nigro-striatal pathway is a main pathological hallmark that requires continuous and focal restoration. Current predominant treatment with intermittent oral administration of its precursor, Levodopa (l-dopa), remains the gold standard but pharmacological drawbacks trigger motor fluctuations and dyskinesia. Continuous intracerebroventricula...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2017
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2017.03.013